Vacation rentals in Santee River, SC

46 available vacation rental offers

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Best vacation rentals and Airbnb offers in Santee River, SC

Beautiful Cottage between Lake Moultrie and Lake Marion - Santee River, SC

Beautiful Cottage between Lake Moultrie and Lake Marion

Holiday Home, Santee River

Beautiful Cottage between Lake Moultrie and Lake Marion is a holiday home in Santee River, with parking and kitchen access. This stay gives travelers a comfortable base for exploring the…

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About Beautiful Cottage between Lake Moultrie and Lake Marion

Beautiful Cottage between Lake Moultrie and Lake Marion is a holiday home in Santee River, with parking and kitchen access. This stay gives travelers a comfortable base for exploring the area, relaxing between outings, and spending time with family or friends.

Useful features: free wifi, kitchen, with kitchen, parking, and free parking.

Sat, Aug 29 - Sat, Sep 5 · 7 nights · total from $962.

From$137/night
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The Beehive is 19 miles from I-95, 16 miles from I-26. Fishing, hunting & more. - Santee River, SC

The Beehive is 19 miles from I-95, 16 miles from I-26. Fishing, hunting & more.

Apartment, Santee River

The Beehive is 19 miles from I-95, 16 miles from I-26. Fishing, hunting & more. is a apartment in Santee River, with kitchen access. This stay gives travelers a comfortable base for…

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About The Beehive is 19 miles from I-95, 16 miles from I-26. Fishing, hunting & more.

The Beehive is 19 miles from I-95, 16 miles from I-26. Fishing, hunting & more. is a apartment in Santee River, with kitchen access. This stay gives travelers a comfortable base for exploring the area, relaxing between outings, and spending time with family or friends.

Useful features: free cancellation, free wifi, kitchen, with kitchen, and washer.

Sat, Aug 29 - Sat, Sep 5 · 7 nights · total from $999.

From$143/night
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Space-Age Glamping Oasis - Immerse Yourself in Nature Without Sacrificing Comfort - Santee River, SC

Space-Age Glamping Oasis - Immerse Yourself in Nature Without Sacrificing Comfort

Holiday Home, Santee River

Space-Age Glamping Oasis - Immerse Yourself in Nature Without Sacrificing Comfort is a holiday home in Santee River, with pet-friendly space, parking, and kitchen access. This stay gives…

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About Space-Age Glamping Oasis - Immerse Yourself in Nature Without Sacrificing Comfort

Space-Age Glamping Oasis - Immerse Yourself in Nature Without Sacrificing Comfort is a holiday home in Santee River, with pet-friendly space, parking, and kitchen access. This stay gives travelers a comfortable base for exploring the area, relaxing between outings, and spending time with family or friends.

Useful features: free cancellation, pet friendly, pets friendly, kitchen, and with kitchen.

Sat, Aug 29 - Sat, Sep 5 · 7 nights · total from $1,130.

From$161/night
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Golf and Lake fun on Santee! Bring your boat or golf clubs! - Santee River, SC

Golf and Lake fun on Santee! Bring your boat or golf clubs!

Holiday Home, Santee River

Golf and Lake fun on Santee! Bring your boat or golf clubs! is a holiday home in Santee River, with parking and kitchen access. This stay gives travelers a comfortable base for exploring…

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About Golf and Lake fun on Santee! Bring your boat or golf clubs!

Golf and Lake fun on Santee! Bring your boat or golf clubs! is a holiday home in Santee River, with parking and kitchen access. This stay gives travelers a comfortable base for exploring the area, relaxing between outings, and spending time with family or friends.

Useful features: free cancellation, free wifi, kitchen, with kitchen, and parking.

Sat, Aug 29 - Sat, Sep 5 · 7 nights · total from $1,151.

From$164/night
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Vacation rentals with parking in Santee River, SC

Find vacation rentals that make arriving by car easier.

Dukes Street Retreat 5min from I-95! - Santee River, SC

Dukes Street Retreat 5min from I-95!

Holiday Home, Santee River

Dukes Street Retreat 5min from I-95! is a holiday home in Santee River, with parking, kitchen access, and a quieter setting. This stay gives travelers a comfortable base for exploring the…

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About Dukes Street Retreat 5min from I-95!

Dukes Street Retreat 5min from I-95! is a holiday home in Santee River, with parking, kitchen access, and a quieter setting. This stay gives travelers a comfortable base for exploring the area, relaxing between outings, and spending time with family or friends.

Useful features: free cancellation, kitchen, with kitchen, parking, and free parking.

Sat, Aug 29 - Sat, Sep 5 · 7 nights · total from $1,463.

From$209/night
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Lakefront, private dock, boat access - Santee River, SC

Lakefront, private dock, boat access

Holiday Home, Santee River

Lakefront, private dock, boat access is a holiday home in Santee River, with parking and kitchen access. This stay gives travelers a comfortable base for exploring the area, relaxing…

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About Lakefront, private dock, boat access

Lakefront, private dock, boat access is a holiday home in Santee River, with parking and kitchen access. This stay gives travelers a comfortable base for exploring the area, relaxing between outings, and spending time with family or friends.

Useful features: free cancellation, free wifi, kitchen, with kitchen, and parking.

Sat, Aug 29 - Sat, Sep 5 · 7 nights · total from $1,585.

From$226/night
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Lakefront 3-bedroom home with private dock and ramp on Lake Marion, Manning, SC - Santee River, SC

Lakefront 3-bedroom home with private dock and ramp on Lake Marion, Manning, SC

Holiday Home, Santee River

Lakefront 3-bedroom home with private dock and ramp on Lake Marion, Manning, SC is a holiday home in Santee River, with parking, kitchen access, and room for a group. This stay gives…

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About Lakefront 3-bedroom home with private dock and ramp on Lake Marion, Manning, SC

Lakefront 3-bedroom home with private dock and ramp on Lake Marion, Manning, SC is a holiday home in Santee River, with parking, kitchen access, and room for a group. This stay gives travelers a comfortable base for exploring the area, relaxing between outings, and spending time with family or friends.

Useful features: free cancellation, kitchen, with kitchen, parking, and free parking.

Sat, Aug 29 - Sat, Sep 5 · 7 nights · total from $1,618.

From$231/night
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Lakefront Retreat At Randolphs Landing - Santee River, SC

Lakefront Retreat At Randolphs Landing

Holiday Home, Santee River

Lakefront Retreat At Randolphs Landing is a holiday home in Santee River, with parking, kitchen access, and a quieter setting. This stay gives travelers a comfortable base for exploring the…

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About Lakefront Retreat At Randolphs Landing

Lakefront Retreat At Randolphs Landing is a holiday home in Santee River, with parking, kitchen access, and a quieter setting. This stay gives travelers a comfortable base for exploring the area, relaxing between outings, and spending time with family or friends.

Useful features: free cancellation, free wifi, kitchen, with kitchen, and parking.

Sat, Aug 29 - Sat, Sep 5 · 7 nights · total from $1,628.

From$233/night
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Pet-friendly vacation rentals in Santee River, SC

Bring your pet along with stays that welcome four-legged travelers.

Taw Caw Creek Rental - perfect for fishermen - NO PETS - Santee River, SC

Taw Caw Creek Rental - perfect for fishermen - NO PETS

Holiday Home, Santee River

Taw Caw Creek Rental - perfect for fishermen - NO PETS is a holiday home in Santee River, with pet-friendly space and parking. This stay gives travelers a comfortable base for exploring the…

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About Taw Caw Creek Rental - perfect for fishermen - NO PETS

Taw Caw Creek Rental - perfect for fishermen - NO PETS is a holiday home in Santee River, with pet-friendly space and parking. This stay gives travelers a comfortable base for exploring the area, relaxing between outings, and spending time with family or friends.

Useful features: free cancellation, parking, free parking, washer, and dryer.

Sat, Aug 29 - Sat, Sep 5 · 7 nights · total from $1,218.

From$174/night
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Beautiful Lake Marion Views!! Pet Friendly! Newly renovated and updated!! - Santee River, SC

Beautiful Lake Marion Views!! Pet Friendly! Newly renovated and updated!!

Holiday Home, Santee River

Beautiful Lake Marion Views!! Pet Friendly! Newly renovated and updated!! is a holiday home in Santee River, with pet-friendly space and kitchen access. This stay gives travelers a…

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About Beautiful Lake Marion Views!! Pet Friendly! Newly renovated and updated!!

Beautiful Lake Marion Views!! Pet Friendly! Newly renovated and updated!! is a holiday home in Santee River, with pet-friendly space and kitchen access. This stay gives travelers a comfortable base for exploring the area, relaxing between outings, and spending time with family or friends.

Useful features: free cancellation, free wifi, pet friendly, pets friendly, and kitchen.

Sat, Aug 29 - Sat, Sep 5 · 7 nights · total from $1,305.

From$186/night
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Marvelous Manning - 4Bdr + Game Room +Waterfront! - Santee River, SC

Marvelous Manning - 4Bdr + Game Room +Waterfront!

Holiday Home, Santee River

Marvelous Manning - 4Bdr + Game Room +Waterfront! is a holiday home in Santee River, with pet-friendly space, easy beach access, and parking. This stay gives travelers a comfortable base…

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About Marvelous Manning - 4Bdr + Game Room +Waterfront!

Marvelous Manning - 4Bdr + Game Room +Waterfront! is a holiday home in Santee River, with pet-friendly space, easy beach access, and parking. This stay gives travelers a comfortable base for exploring the area, relaxing between outings, and spending time with family or friends.

Useful features: free cancellation, pet friendly, pets friendly, kitchen, and with kitchen.

Sat, Aug 29 - Sat, Sep 5 · 7 nights · total from $1,461.

From$209/night
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Vacation rentals with a kitchen in Santee River, SC

Compare stays with kitchen access for longer trips and easier meals.

Lake Moultrie Access: Moncks Corner Home w/ Dock - Santee River, SC

Lake Moultrie Access: Moncks Corner Home w/ Dock

Cottage, Santee River

Lake Moultrie Access: Moncks Corner Home w/ Dock is a cottage in Santee River, with parking and kitchen access. This stay gives travelers a comfortable base for exploring the area, relaxing…

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About Lake Moultrie Access: Moncks Corner Home w/ Dock

Lake Moultrie Access: Moncks Corner Home w/ Dock is a cottage in Santee River, with parking and kitchen access. This stay gives travelers a comfortable base for exploring the area, relaxing between outings, and spending time with family or friends.

Useful features: free cancellation, free wifi, kitchen, with kitchen, and parking.

Sat, Aug 29 - Sat, Sep 5 · 7 nights · total from $1,921.

From$213/night
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Annie's Place- A great Day at Lake Marion, SC - Santee River, SC

Annie's Place- A great Day at Lake Marion, SC

Holiday Home, Santee River

Annie's Place- A great Day at Lake Marion, SC is a holiday home in Santee River, with pet-friendly space and kitchen access. This stay gives travelers a comfortable base for exploring the…

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About Annie's Place- A great Day at Lake Marion, SC

Annie's Place- A great Day at Lake Marion, SC is a holiday home in Santee River, with pet-friendly space and kitchen access. This stay gives travelers a comfortable base for exploring the area, relaxing between outings, and spending time with family or friends.

Useful features: free cancellation, free wifi, pet friendly, pets friendly, and kitchen.

Sat, Aug 29 - Sat, Sep 5 · 7 nights · total from $1,518.

From$217/night
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The Lake House at Turtle Cove: Cozy relaxing lake home with dock on wooded lot. - Santee River, SC

The Lake House at Turtle Cove: Cozy relaxing lake home with dock on wooded lot.

Holiday Home, Santee River

The Lake House at Turtle Cove: Cozy relaxing lake home with dock on wooded lot. is a holiday home in Santee River, with parking, kitchen access, and a quieter setting. This stay gives…

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About The Lake House at Turtle Cove: Cozy relaxing lake home with dock on wooded lot.

The Lake House at Turtle Cove: Cozy relaxing lake home with dock on wooded lot. is a holiday home in Santee River, with parking, kitchen access, and a quieter setting. This stay gives travelers a comfortable base for exploring the area, relaxing between outings, and spending time with family or friends.

Useful features: free cancellation, free wifi, kitchen, with kitchen, and parking.

Sat, Aug 29 - Sat, Sep 5 · 7 nights · total from $1,627.

From$232/night
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Cabin on Lake Moultrie in Bonneau Beach - private boat ramp & dock - Santee River, SC

Cabin on Lake Moultrie in Bonneau Beach - private boat ramp & dock

Holiday Home, Santee River

Cabin on Lake Moultrie in Bonneau Beach - private boat ramp & dock is a holiday home in Santee River, with easy beach access, parking, and kitchen access. This stay gives travelers a…

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About Cabin on Lake Moultrie in Bonneau Beach - private boat ramp & dock

Cabin on Lake Moultrie in Bonneau Beach - private boat ramp & dock is a holiday home in Santee River, with easy beach access, parking, and kitchen access. This stay gives travelers a comfortable base for exploring the area, relaxing between outings, and spending time with family or friends.

Useful features: free cancellation, kitchen, with kitchen, parking, and free parking.

Sat, Aug 29 - Sat, Sep 5 · 7 nights · total from $1,888.

From$270/night
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Family-friendly vacation rentals in Santee River, SC

Plan a trip with stays that give families more room to spread out.

Pet friendly country cottage with large fenced-in yard & horses on property - Santee River, SC

Pet friendly country cottage with large fenced-in yard & horses on property

Cottage, Santee River

Pet friendly country cottage with large fenced-in yard & horses on property is a cottage in Santee River, with pet-friendly space and kitchen access. This stay gives travelers a comfortable…

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About Pet friendly country cottage with large fenced-in yard & horses on property

Pet friendly country cottage with large fenced-in yard & horses on property is a cottage in Santee River, with pet-friendly space and kitchen access. This stay gives travelers a comfortable base for exploring the area, relaxing between outings, and spending time with family or friends.

Useful features: free cancellation, free wifi, pet friendly, pets friendly, and kitchen.

Sat, Aug 29 - Sat, Sep 5 · 7 nights · total from $966.

From$138/night
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Cozy 2-bedroom Cottage with Deck and Lake View - Santee River, SC

Cozy 2-bedroom Cottage with Deck and Lake View

Cottage, Santee River

Cozy 2-bedroom Cottage with Deck and Lake View is a cottage in Santee River, with pet-friendly space, outdoor space, and room for a group. This stay gives travelers a comfortable base for…

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About Cozy 2-bedroom Cottage with Deck and Lake View

Cozy 2-bedroom Cottage with Deck and Lake View is a cottage in Santee River, with pet-friendly space, outdoor space, and room for a group. This stay gives travelers a comfortable base for exploring the area, relaxing between outings, and spending time with family or friends.

Useful features: free cancellation, pet friendly, pets friendly, ac, and air conditioning.

Sat, Aug 29 - Sat, Sep 5 · 7 nights · total from $1,354.

From$193/night
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Three Little Birds Canal Home - Santee River, SC

Three Little Birds Canal Home

Cottage, Santee River

Three Little Birds Canal Home is a cottage in Santee River, with pet-friendly space and kitchen access. This stay gives travelers a comfortable base for exploring the area, relaxing between…

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About Three Little Birds Canal Home

Three Little Birds Canal Home is a cottage in Santee River, with pet-friendly space and kitchen access. This stay gives travelers a comfortable base for exploring the area, relaxing between outings, and spending time with family or friends.

Useful features: free cancellation, pet friendly, pets friendly, kitchen, and with kitchen.

Sat, Aug 29 - Sat, Sep 5 · 7 nights · total from $1,422.

From$203/night
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New! Lakefront Hideaway - Peaceful & Serene & Filled w Nature - Santee River, SC

New! Lakefront Hideaway - Peaceful & Serene & Filled w Nature

Holiday Home, Santee River

New! Lakefront Hideaway - Peaceful & Serene & Filled w Nature is a holiday home in Santee River, with pet-friendly space and kitchen access. This stay gives travelers a comfortable base for…

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About New! Lakefront Hideaway - Peaceful & Serene & Filled w Nature

New! Lakefront Hideaway - Peaceful & Serene & Filled w Nature is a holiday home in Santee River, with pet-friendly space and kitchen access. This stay gives travelers a comfortable base for exploring the area, relaxing between outings, and spending time with family or friends.

Useful features: free cancellation, pet friendly, pets friendly, kitchen, and with kitchen.

Sat, Aug 29 - Sat, Sep 5 · 7 nights · total from $1,992.

From$285/night
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